S961 TFA (1083433-49-1 free base)( —— )

Catalog No. M30060 CAS No. ——

COA

Datasheet

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Product Name

S961 TFA (1083433-49-1 free base)
Note

Research use only, not for human use.
Brief Description

S961 TFA is A high affinity insulin receptor (IR) antagonist with IC50 for hir-a, hir-b and human insulin-like growth factor I receptor (higf-ir) at 0.048, 0.027 and 630 nM, respectively.
Description

S961 TFA is A high affinity insulin receptor (IR) antagonist with IC50 for hir-a, hir-b and human insulin-like growth factor I receptor (higf-ir) at 0.048, 0.027 and 630 nM, respectively.(In Vitro):S961 also shows high-affinity to Rat IR and Pig IR with IC50s of 0.056 nM and 0.084 nM in PEG-assay, respectively.
In Vitro

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In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

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Research Area

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Indication

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CAS Number

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Formula Weight

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Molecular Formula

C211H297N55O71S2.xC2HF3O2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

Sequence:{Gly}{Ser}{Leu}{Asp}{Glu}{Ser}{Phe}{Tyr}{Asp}{Trp}{Phe}{Glu}{Arg}{Gln}{Leu}{Gly}{Gly}{Gly}{Ser}{Gly}{Gly}{Ser}{Ser}{Leu}{Glu}{Glu}{Glu}{Trp}{Ala}{Gln}{Ile}{Gln}{Cys}{Glu}{Val}{Trp}{Gly}{Arg}{Gly}{Cys}{Pro}{Ser}{Tyr} (Disulfide bridge: Cys33-Cys40)

Sch?ffer L, et al. A novel high-affinity peptide antagonist to the insulin receptor. Biochem Biophys Res Commun. 2008 Nov 14;376(2):380-3.

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